Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy. The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling. Reactive oxygen species at phospholipid bilayers: distribution, mobility and permeation. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Insights into the post-transcriptional regulation of the mitochondrial electron transport chain. Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain. Structure and mechanism of mitochondrial electron transport chain. Melatonin and the electron transport chain. ROS and energy metabolism in cancer cells: alliance for fast growth. Can all major ROS forming sites of the respiratory chain be activated by high FADH2 /NADH ratios?: ancient evolutionary constraints determine mitochondrial ROS formation. Stem cells and the impact of ROS signaling. Regulation of mitochondrial electron transport chain assembly. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Reactive oxygen species (ROS) are a key determinant of cancer's metabolic phenotype. Reactive oxygen species in metabolic and inflammatory signaling. Mitochondrial ROS signaling in organismal homeostasis. Mitochondria: much ado about nothing? How dangerous is reactive oxygen species production? Int J Biochem Cell Biol. Reactive oxygen species (ROS) and response of antioxidants as ROS-scavengers during environmental stress in. In this chapter, we focus on the interaction between ROS and lipid metabolism, especially the effects of ROS on the synthesis and oxidation of fatty acids, as well as phospholipids, cholesterol, and browning of beige fat. This review aims to clarify the role of ROS in regulating glucose metabolism (glucose uptake, glycolysis, gluconeogenesis, glycogen synthesis, glycogenolysis, pentose phosphate pathway).Īs we all know, ROS plays a very important role in the pathogenesis of metabolic diseases induced by dysregulation of lipid metabolism, such as obesity, nonalcoholic fatty liver disease, and atherosclerosis. Generally, glucose metabolism increases the production of ROS and enhances oxidative stress by glucose auto-oxidation and glycosylation of proteins and activated the polyalcohol pathway, etc. In recent years, a large amount of evidence has demonstrated that ROS plays a pivotal role in regulating cell glucose and lipid metabolism and participates in the occurrence and development of disorders related to glucose and lipid metabolism. The mitochondrial respiratory chain complex is regarded as a major ROS producer, which is composed of four protein complexes, the complex I, complex II, complex III, and complex IV. Reactive oxygen species (ROS) are free radicals produced by the reduction of molecular oxygen.
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